The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members.

The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network.

Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health.

The Junior Clinical Cooperation Unit "Translational Gastrointestinal Oncology and Preclincial Models" at the German Cancer Reserch Center is seeking for the next possible date a

Postdoctoral Researcher in Translational Control & Cancer-Microbiome Interactions

Reference number: 2025-0311

• Heidelberg, Mannheim
• Full-time
• Translational Gastrointestinal Oncology and Preclinical Models

The Junior Clinical Cooperation Unit (headed by Prof. Dr. med. Johannes Betge) aims to identify cancer vulnerabilities and uncover mechanisms of treatment resistance by using patient-derived cancer models and high-throughput methods, such as drug screening, -omics, and single-cell technologies. Together with the group of Dr. Johanna Schott (Department of Biochemistry, Mannheim Medical Faculty), focused on RNA biology and mechanisms of translation control, we offer a postdoctoral position within the framework of the newly funded Research Unit „Functional Genomics and Microbiomics in Precision Medicine of Colorectal Cancer“ (GenoMiCC, FOR 5806).

Your Tasks

• Gain important insights into clinically relevant aspects of colorectal cancer biology and influences of microbiota
• Apply a wide spectrum of genetic, molecular, cell biological, biochemical as well as -omics and bioinformatics techniques
• Optimize and apply ribosome profiling and single-cell ribosome profiling on organoids and clinical samples
• Characterize the impact of gut microbiota-derived metabolites on signalling pathways, translation control, and therapy resistance in patient-derived colorectal cancer organoids and clinical samples
• Interact within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists, and other colleagues within our research groups and with consortium partners of the FOR 5806

Your Profile

We are looking for a self-motivated, bright individual with a master's and PhD degree in biochemistry, biology, bioinformatics, molecular medicine, or a related subject. Previous experience with biochemical and molecular biology techniques, as well as a strong interest in molecular cancer research, are essential. Prior experience with RNA biology, organoid models, high-throughput methods, or -omics analysis is an advantage, but not mandatory. Due to the interdisciplinary framework and close collaboration between two labs and within the FOR 5806, excellent communication skills in English, the ability to work independently, and strong organizational skills are expected.

We Offer

• Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
• Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
• 30 days of vacation per year
• Flexible working hours
• Possibility of part-time work
• Family-friendly working environ­ment
• Sustainable travel to work: subsidized Germany job ticket
• Our Corporate Health Manage­ment Program offers a holistic approach to your well-being
• Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents

Contact:
PD Dr. med. Johannes Betge
Phone: +49 (0)6221/42-1965

The position is initially limited to 2 years, with the possibility of prolongation.

Application Deadline: 17.01.2026

Applications by e-mail cannot be accepted.
Please also note that we cannot return applications submitted by post.

Are you interested?

Then become part of the DKFZ and join us in contributing to a life without cancer!

We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

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